Author

Maurice Besch

University of ViennaORCID 0000-0001-9242-0261Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Christoph RademacheriD· 2 shared Jonathan LefèbreiD· 2 shared Annika BalkeiD· 1 shared Bettina G. KelleriD· 1 shared Carlos Pablo ModenuttiiD· 1 shared Elena Georgieva· 1 shared Gitta SchlosseriD· 1 shared Gregor Suchy· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Christoph RademacherORCID

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2 papers

Recent·Most cited

BiochemistryJACS AuPeer-reviewedJan 20, 2026

A cryptic pocket allosterically modulates oligosaccharide binding to DC-SIGN

Jonathan Lefèbre, Maurice Besch, Marcelo Daniel Gamarra…·Christoph Rademacher

The paper identifies a cryptic allosteric pocket in DC-SIGN that modulates oligosaccharide binding through conformational changes and residue mutations.

7 citationstop 2%

humanstructural biology

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Pharmacology & ToxicologyAngewandte Chemie International EditionPeer-reviewedNov 24, 2025

Covalent activation of the C-type lectin DC-SIGN

Jonathan Lefèbre, Maurice Besch, Noémi Csorba…·Christoph Rademacher

This paper identifies two covalent activators of DC-SIGN by screening a lysine-targeted electrophilic fragment library, revealing distinct mechanisms of activation through structural and functional analyses.

9 citations

proteomicsdeep learning

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