Carlos Pablo Modenutti

The paper identifies a cryptic allosteric pocket in DC-SIGN that modulates oligosaccharide binding through conformational changes and residue mutations.

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

The paper identifies DAF-12 orthologs in Meloidogyne incognita using HMM-based sequence search and structural bioinformatics, showing conserved ligand binding site despite low sequence similarity.

The paper introduces a computational method combining molecular docking and dynamics simulations to identify key amino acids in a viral protein's Carbohydrate Recognition Domain, validated by in vitro experiments.

The paper improves SLiM prediction by integrating variant data and structural analysis of SAS impacts, enhancing specificity and variant classification in clinical genomics.

VarQ assesses the functional impact of single amino acid substitutions on protein activity, folding, and interactions using curated variants.