Christoph Rademacher

The paper evaluates how glycan-binding proteins and immune cells recognize mirror-image glycans, finding widespread binding and donor-specific recognition of L-glycans.

This study develops a targeted mRNA delivery system to Langerhans cells, enhancing anti-tumor immunity while reducing required doses.

The paper identifies a cryptic allosteric pocket in DC-SIGN that modulates oligosaccharide binding through conformational changes and residue mutations.

This paper identifies two covalent activators of DC-SIGN by screening a lysine-targeted electrophilic fragment library, revealing distinct mechanisms of activation through structural and functional analyses.

This study shows that targeting protein antigens to Langerhans cells enhances antigen-specific T cell activation and immune response compared to unmodified antigens.

The paper investigates how pH affects calcium binding in langerin by simulating protonation effects and conformational changes.