Leveraging chromatin packing domains to target chemoevasion in vivo
Jane Frederick, Ranya K. A. Virk, I Chae Ye, Luay Matthew Almassalha, Greta Wodarcyk, David VanDerway, Ruyi Gong, Cody L. Dunton, Tiffany Kuo, Karla Medina, Margarita Loxas, Jared T. Ahrendsen, Demirkan Besim Gursel, Paola Carrillo Gonzalez, Rikkert J. Nap, , Vadim Backman
This study develops a physics-based model linking chromatin organization to chemoevasion, identifies TPR compounds that enhance chemotherapy efficacy in ovarian cancer.
Proceedings of the National Academy of Sciences · Jul 22, 2025Peer-reviewedBiophysics