Author

Ranya K. A. Virk

Northwestern UniversityORCID 0000-0002-9652-2801Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Assay:Hi-C· 1 Assay:imaging· 1

Frequent Co-Authors

Igal G. SzleiferiD· 4 shared Vadim BackmaniD· 4 shared Jane FrederickiD· 3 shared Luay Matthew AlmassalhaiD· 3 shared Vasundhara AgrawaliD· 3 shared Adam EsheiniD· 2 shared David VanDerwayiD· 2 shared Juan PabloiD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

Igal G. SzleiferORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Leveraging chromatin packing domains to target chemoevasion in vivo

Jane Frederick, Ranya K. A. Virk, I Chae Ye, Luay Matthew Almassalha, Greta Wodarcyk, David VanDerway, Ruyi Gong, Cody L. Dunton, Tiffany Kuo, Karla Medina, Margarita Loxas, Jared T. Ahrendsen, Demirkan Besim Gursel, Paola Carrillo Gonzalez, Rikkert J. Nap, , Vadim Backman

This study develops a physics-based model linking chromatin organization to chemoevasion, identifies TPR compounds that enhance chemotherapy efficacy in ovarian cancer.

Proceedings of the National Academy of Sciences · Jul 22, 2025Peer-reviewedBiophysics

The Impact of Charge Regulation and Ionic Intranuclear Environment on the Nucleosome Core Particle

Rikkert J. Nap, Paola Carrillo Gonzalez, A. E. Coraor, Ranya K. A. Virk, Juan Pablo, Vadim Backman, Igal G. Szleifer

This study theoretically examines how intranuclear factors like salt concentration and pH affect the charge state of nucleosome core particles, highlighting the role of magnesium ions and molecular details.

The Journal of Chemical Physics · Dec 20, 2024Peer-reviewedBiophysics

Statistical Analysis of Three-Dimensional Chromatin Packing Domains Determined by Chromatin Scanning Transmission Electron Microscopy (ChromSTEM)

Yue Li, Vasundhara Agrawal, Ranya K. A. Virk, Eric W. Roth, Wing Shun Li, Adam Eshein, Jane Frederick, Kai Huang, Luay Matthew Almassalha, Reiner Bleher, Marcelo A. Carignano, Igal G. Szleifer, Vinayak P. Dravid, Vadim Backman

The paper introduces ChromSTEM, a method for high-resolution 3D imaging of chromatin structure, and finds that chromatin forms well-defined domains around 100 nm in radius with radially decreasing mass-density.

bioRxiv · May 24, 2021 · PreprintGenomics

Nanoscale Chromatin Imaging and Analysis (nano-ChIA) platform bridges 4-D chromatin organization with molecular function

Yue Li, Adam Eshein, Ranya K. A. Virk, Aya Eid, Wenli Wu, Jane Frederick, David VanDerway, Scott Gladstein, Kai Huang, Nicholas M. Anthony, Greta M. Bauer, Xiang Zhou, Vasundhara Agrawal, Emily M. Pujadas-Liwag, George Esteve, , Vadim Backman

The paper introduces a nano-ChIA platform that combines electron tomography and superresolution imaging to study chromatin structure and dynamics at the single-nucleosome level in live cells.

Microscopy and Microanalysis · Jul 30, 2020Peer-reviewedGenomics