Pre-clinical efficacy of a C4BP hexameric IgG Fc fusion protein against Neisseria gonorrhoeae
Jutamas Shaughnessy, Jintang Du, Mary W. Broden, Sunita Gulati, Bo Zheng, Nancy Nowak, Gretchen Telford, Sandy P Fontes, Yen T. B. Tran, Keith L. Wycoff, Kevin J. Whaley, Alison K. Criss, Sanjay Ram
This paper demonstrates that a hexameric C4BP IgG Fc fusion protein significantly enhances complement-dependent bactericidal activity and reduces gonococcal vaginal colonization in mice.
PLoS ONE · Aug 25, 2026Peer-reviewedImmunology