Alison K. Criss

This paper demonstrates that a hexameric C4BP IgG Fc fusion protein significantly enhances complement-dependent bactericidal activity and reduces gonococcal vaginal colonization in mice.

This study shows C4BP inhibits Neisseria gonorrhoeae's interaction with neutrophil CEACAMs, reducing phagocytic killing by blocking Opa-CEACAM binding.

This paper develops a microphysiologic model of the cervical epithelium that replicates microbial, immunologic, and pathogenic features of STIs caused by Chlamydia and Neisseria.

This study shows that terminal complement complexes, with or without C9, enhance antimicrobial activity against Neisseria gonorrhoeae, re-sensitizing drug-resistant strains to antibiotics.

This study investigates cross-species immune responses induced by meningococcal OMV vaccines and their association with protection against N. gonorrhoeae.

The paper introduces a 22-color spectral flow cytometry panel to profile human PMNs for activation, degranulation, phagocytosis, and other responses using phorbol ester and bacterial challenges.

This study uses dual-species RNA-seq to analyze the transcriptional responses of Neisseria gonorrhoeae and human neutrophils during infection, revealing shared metabolic and immunologic processes.