The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing
Colin E Fowler, Natalie A. O’Hearn, Griffin J. Salus, Arundeep Singh, Paul L. Boutz, Jacqueline A. Lees
The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.
iScience · Jun 20, 2025Peer-reviewedCancer Biology