Author

Colin E Fowler

Koch Institute for Integrative Cancer Research At MITORCID 0000-0002-6281-2851Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Jacqueline A. LeesiD· 2 shared Natalie A. O’Hearn· 2 shared Yadira M. Soto‐FelicianoiD· 2 shared Ziyang YeiD· 2 shared Agata L. PatriotisiD· 1 shared Alireza Khademi· 1 shared Amy E. KeatingiD· 1 shared Anthony J. GriffeniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

Jacqueline A. LeesORCID

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3 papers

Recent·Most cited

PRMT5 inhibition induces a histone methylation switch that drives chromatin plasticity, drug resistance, and metastatic progression

Colin E Fowler, Natalie A. O’Hearn, Nicole Henning, Anthony J. Griffen, Ziyang Ye, Nicolas Mathey‐Andrews, Griffin Salus, Renin Hazan, Tyler Jacks, Aurora Burds, Helen Mueller, Yadira M. Soto‐Feliciano, Lindsay LaFave, Jacqueline A. Lees

This study shows PRMT5 inhibition causes splicing defects and epigenetic changes leading to drug resistance and metastatic progression in lung adenocarcinoma.

bioRxiv · Oct 10, 2026 · PreprintCancer Biology

Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate

Ziyang Ye, Alireza Khademi, Renée Louane Barbosa, Foster Birnbaum, Margaret R. Brown, Colin E Fowler, Arianna Arroyo-Ortega, Daniel Lee, Lijuan Feng, Leah A. Gates, Agata L. Patriotis, Amy E. Keating, Francisco J. Sánchez Rivera, Yadira M. Soto‐Feliciano

This study develops CHANCLA, a multiomic platform to screen oncohistones, revealing their impact on chromatin and cell fate through functional and structural analyses.

bioRxiv · Apr 17, 2026 · PreprintCancer Biology

The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing

Colin E Fowler, Natalie A. O’Hearn, Griffin J. Salus, Arundeep Singh, Paul L. Boutz, Jacqueline A. Lees

The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.

iScience · Jun 20, 2025Peer-reviewedCancer Biology