Author
Koch Institute for Integrative Cancer Research At MIT
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Colin E Fowler, Natalie A. O’Hearn, Nicole Henning…·Jacqueline A. Lees
This study shows PRMT5 inhibition causes splicing defects and epigenetic changes leading to drug resistance and metastatic progression in lung adenocarcinoma.
Shandon M Amos, Chi-Chao Chen, Yichen Xiang…·Yadira M. Soto‐Feliciano
This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.
Colin E Fowler, Natalie A. O’Hearn, Griffin J. Salus…·Jacqueline A. Lees
The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.