Paul L. Boutz

This study identifies ZC3H18 mutations that stabilize endogenous retroviral RNA, linking ERV RNA accumulation to oncogenesis in zebrafish and human cell lines.

This study shows CDK12 and CDK13 suppress distinct intronic polyadenylation sites, leading to premature termination and novel peptides in cancer.

This study investigates how PUF60 expression changes affect splicing patterns and reveals a phosphorylation-mediated regulatory mechanism in mouse stem cells.

This study shows SF3B1 phosphorylation reduces its binding to U2AF2, enabling widespread control of pre-mRNA splicing by promoting U2AF2 dissociation.

The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.