Author

Arundeep Singh

Koch Institute for Integrative Cancer Research At MITORCID 0000-0003-2342-9486Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Brandon Sullivan· 1 shared Colin E FowleriD· 1 shared Dig Bijay MahatiD· 1 shared Emily MetcalfiD· 1 shared Enrico MoisoiD· 1 shared Griffin J. Salus· 1 shared Heena KumraiD· 1 shared Hernandez Moura SilvaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Brandon Sullivan

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2 papers

Recent·Most cited

Cancer BiologyImmunityPeer-reviewedJul 1, 2025

Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer

Dig Bijay Mahat, Heena Kumra, Sarah A Castro…·Phillip A. Sharp

This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.

44 citationstop 1%

humanbulk RNA-seq

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Cancer BiologyiSciencePeer-reviewedJun 20, 2025

The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing

Colin E Fowler, Natalie A. O’Hearn, Griffin J. Salus…·Jacqueline A. Lees

The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.

4 citations

humanmouse

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