Li‐Lin Du

Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast

The paper examines natural variation in galactose and melibiose metabolism in fission yeast, identifying gene loss, repression, amplification, and horizontal gene transfer as mechanisms shaping metabolic diversity.

Schizosaccharomyces orthogroup (SOG) resource: a web platform for exploring gene conservation in fission yeasts

The paper introduces a web platform for exploring gene conservation in fission yeasts using orthogroup data from multiple species.

Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast

This study identifies Npr1 as a nucleophagy receptor in fission yeast and shows that chromatin-nuclear envelope tethering inhibits nucleophagy.

Evolutionary persistence and divergence of the tdk killer meiotic driver family

The paper identifies divergent tdk1 homologs in fission yeast as active killer meiotic drivers, showing functional divergence and long-term evolutionary persistence.

Global analysis of protein and small-molecule substrates of ubiquitin-like proteins (UBLs)

The paper introduces pLink-UBL, a software tool for identifying UBL modification sites on proteins and small-molecule substrates, and discovers spermidine as a small-molecule substrate of SUMO in fission yeast and mammals.

Evolutionary modes of wtf meiotic driver genes in Schizosaccharomyces pombe

The paper investigates the evolutionary mechanisms of wtf meiotic driver genes in S. pombe using long-read genome assemblies and identifies gene conversion and recombination events contributing to their diversity and persistence.

An improved tetracycline-inducible expression system for fission yeast

This paper introduces an improved tetracycline-inducible expression system for fission yeast that enables control of gene expression in non-dividing cells and supports synchronous meiosis induction.

A high-quality reference genome for the fission yeast Schizosaccharomyces osmophilus

This paper presents a high-quality reference genome for S. osmophilus, a newly identified fission yeast species, and uses it to conduct comparative genomic analyses across fission yeast species.

An improved auxin-inducible degron system for fission yeast

This paper improves the auxin-inducible degron system in fission yeast by optimizing the degron, inducer, and F-box protein, achieving inducible lethality for essential genes.

Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats

The paper identifies Mck1 as a key S-phase checkpoint effector that regulates dNTP homeostasis by modulating RNR and HUG1 expression in response to replication threats.

A cloning-free method for CRISPR/Cas9-mediated genome editing in fission yeast

This paper introduces a cloning-free CRISPR/Cas9 method for genome editing in fission yeast using gap repair to assemble plasmids and sgRNA inserts.