Nuclear envelope-dependent heterochromatin positioning gates the timing of nucleolar assembly in the early embryo
X. X. Ding, Guanzhi Wang, Daniel Elnatan, Matthew Laurence, Sara Zdanovskis, Megan Couture, Stephanie C. Weber, Daniel A. Starr, G. W. Gant Luxton
The paper shows that the LINC complex and nuclear lamina delay nucleolar assembly in C. elegans embryos by organizing heterochromatin, with CEC-4 playing a key role in suppressing premature nucleoli.
bioRxiv · Jul 22, 2026 · PreprintCell Biology