Daniel Elnatan

Nuclear envelope-dependent heterochromatin positioning gates the timing of nucleolar assembly in the early embryo

The paper shows that the LINC complex and nuclear lamina delay nucleolar assembly in C. elegans embryos by organizing heterochromatin, with CEC-4 playing a key role in suppressing premature nucleoli.

The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration

The paper shows UNC-83 isoforms differentially regulate kinesin-1 and dynein to control nuclear migration directionality during development.

Active Microtubule-Actin Crosstalk Mediated by a Nesprin-2G-Kinesin Complex

This study identifies N2G as an F-actin bundler and kinesin-1 activator that mediates active microtubule-actin crosstalk, crucial for nuclear positioning.

Giant KASH proteins and ribosomes synergistically establish cytoplasmic biophysical properties in vivo

The paper identifies two conserved mechanisms controlling cytoplasmic macromolecular diffusion in C. elegans tissues, involving ribosome concentration and the giant KASH protein ANC-1.

FLN-2 functions in parallel to LINC complexes and Cdc42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans

The paper identifies FLN-2 as a third pathway mediating P-cell nuclear migration in C. elegans, functioning alongside LINC complexes and CDC-42/actin pathways to maintain nuclear envelope integrity during migration through constricted spaces.

Diffusion and distal linkages govern interchromosomal dynamics during meiotic prophase

The paper uses live imaging and modeling to show that random diffusion and a small number of linkages suffice for homolog pairing during meiosis in budding yeast.

Phenotype to genotype mapping using supervised and unsupervised learning

This paper develops a framework combining CNN and unsupervised learning to map genotype to vacuole morphology in yeast, identifying 4 phenotypic groups with 85% purity and 80% prediction accuracy.

Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

The paper shows ATP hydrolysis in TRAP1 is sequential and asymmetric, with conformational flipping during the cycle to remodel client proteins.