G. W. Gant Luxton

A novel FRET-force biosensor for nucleoporin gp210 reveals that the nuclear pore complex experiences mechanical tension

The paper develops a FRET-force biosensor to measure mechanical tension on the nuclear pore complex and finds that nuclear strain, not cytoskeletal forces, primarily drives these forces.

Nuclear envelope-dependent heterochromatin positioning gates the timing of nucleolar assembly in the early embryo

The paper shows that the LINC complex and nuclear lamina delay nucleolar assembly in C. elegans embryos by organizing heterochromatin, with CEC-4 playing a key role in suppressing premature nucleoli.

LGBTQ+ realities in the biological sciences

This study surveys LGBTQ+ biologists to assess workplace climate and belonging, finding lower morale and exclusionary experiences among transgender and gender non-conforming scientists.

Muscular dystrophy-associated lamin variants disrupt cellular organization through a nucleolar-ribosomal axis controlling cytoplasmic macromolecular crowding

This study identifies a nucleolar-ribosomal axis linking lamin mutations to cytoplasmic biophysical changes in EDMD, revealing a new pathway for laminopathy pathogenesis.

The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration

The paper shows UNC-83 isoforms differentially regulate kinesin-1 and dynein to control nuclear migration directionality during development.

Active Microtubule-Actin Crosstalk Mediated by a Nesprin-2G-Kinesin Complex

This study identifies N2G as an F-actin bundler and kinesin-1 activator that mediates active microtubule-actin crosstalk, crucial for nuclear positioning.

Giant KASH proteins and ribosomes synergistically establish cytoplasmic biophysical properties in vivo

The paper identifies two conserved mechanisms controlling cytoplasmic macromolecular diffusion in C. elegans tissues, involving ribosome concentration and the giant KASH protein ANC-1.

Anchorage of H3K9-methylated heterochromatin to the nuclear periphery helps mediate P-cell nuclear migration though constricted spaces in Caenorhabditis elegans

The paper shows that anchoring H3K9-methylated heterochromatin to the nuclear periphery is necessary for P-cell nuclear migration through constrictions in C. elegans, independent of the LINC complex.

FLN-2 functions in parallel to LINC complexes and Cdc42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans

The paper identifies FLN-2 as a third pathway mediating P-cell nuclear migration in C. elegans, functioning alongside LINC complexes and CDC-42/actin pathways to maintain nuclear envelope integrity during migration through constricted spaces.

A CDC-42-regulated actin network is necessary for nuclear migration through constricted spaces in C. elegans

The paper identifies CDC-42 and the Arp2/3 complex as regulators of nuclear migration in C. elegans P-cells, functioning parallel to the LINC complex.

Whole exome sequencing identifies novel DYT1 dystonia-associated genome variants as potential disease modifiers

The paper identifies novel genome variants associated with DYT1 dystonia through whole exome sequencing and suggests they may modify disease penetrance.

A synthetic biology platform for the reconstitution and mechanistic dissection of LINC complex assembly

This paper introduces a synthetic biology platform to reconstitute and study LINC complex assembly using artificial nuclear membranes and cell-free expression.