A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages
Yongliang Tong, Runqiu Chen, Xinrong Lu, Cuiying Chen, Gui-qin Sun, Xiaolu Yu, Shaoxian Lyu, Meiqing Feng, Yiru Long, Likun Gong, Li Chen
This study develops a nanobody-enzyme fusion protein targeting PD-L1 and sialic acid, showing anti-tumor effects by modulating tumor-associated macrophages.
International Journal of Biological Macromolecules · Jan 15, 2025Peer-reviewedPharmacology & Toxicology