Likun Gong

This study identifies the endothelial cell-NK cell-neutrophil axis as a key driver of STING agonist-induced pulmonary inflammation and toxicity.

This study identifies metabolic reprogramming as a mechanism by which CTLA-4 inhibitors cause colitis, showing that metformin can alleviate this toxicity without affecting antitumor efficacy.

This study develops a nanobody-enzyme fusion protein targeting PD-L1 and sialic acid, showing anti-tumor effects by modulating tumor-associated macrophages.

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.