Osmo-hydraulic volume regulation ensures robust endothelial-to-haematopoietic transition
Igor Kondrychyn, Yan Chen, Rajrishi Kumar, Jason A. da Silva, Haymar Wint, Guihua Chen, Koichi Kawakami, Eóin McEvoy, Li‐Kun Phng
The paper identifies an osmo-hydraulic volume-regulation mechanism in haemogenic endothelial cells during endothelial-to-haematopoietic transition, showing it maintains cell integrity and HSPC production.
bioRxiv · Sep 16, 2026 · PreprintBiophysics