Li‐Kun Phng

The paper identifies an osmo-hydraulic volume-regulation mechanism in haemogenic endothelial cells during endothelial-to-haematopoietic transition, showing it maintains cell integrity and HSPC production.

Mural-VISTA quantifies 3D mural cell morphology and vessel interactions, revealing cell-type specific effects of RhoA activity on branch complexity and solidity.

The paper shows that Piezo1 mediates fluid shear stress-induced nuclear remodeling and chromatin reorganization in endothelial cells by linking cytoplasmic and nuclear mechanotransduction.

This study shows that mural cell contractility and morphology jointly regulate vessel diameter in zebrafish, with vSMCs stabilizing diameter and pericytes having a lesser role.

This study identifies circumferential actomyosin bundles as drivers of endothelial cell deformations that regulate vessel diameter and prevent vascular malformations.

This study identifies Rasip1's role in regulating actomyosin contractility to initiate lumen formation from junctions in zebrafish.

This study shows that endothelial tip cells use hydrostatic pressure and actin polymerization to migrate and sprout blood vessels, with Aqp1a.1 and Aqp8a.1 playing a key role in this process.