Haymar Wint

The paper identifies an osmo-hydraulic volume-regulation mechanism in haemogenic endothelial cells during endothelial-to-haematopoietic transition, showing it maintains cell integrity and HSPC production.

The paper shows that Piezo1 mediates fluid shear stress-induced nuclear remodeling and chromatin reorganization in endothelial cells by linking cytoplasmic and nuclear mechanotransduction.

This study shows that endothelial tip cells use hydrostatic pressure and actin polymerization to migrate and sprout blood vessels, with Aqp1a.1 and Aqp8a.1 playing a key role in this process.