Igor Kondrychyn

Osmo-hydraulic volume regulation ensures robust endothelial-to-haematopoietic transition

The paper identifies an osmo-hydraulic volume-regulation mechanism in haemogenic endothelial cells during endothelial-to-haematopoietic transition, showing it maintains cell integrity and HSPC production.

Circumferential actomyosin bundles drive endothelial cell deformations to constrict blood vessels

This study identifies circumferential actomyosin bundles as drivers of endothelial cell deformations that regulate vessel diameter and prevent vascular malformations.

Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

This study shows that endothelial tip cells use hydrostatic pressure and actin polymerization to migrate and sprout blood vessels, with Aqp1a.1 and Aqp8a.1 playing a key role in this process.

High behavioural variability mediated by altered neuronal excitability in auts2 mutant zebrafish

This study investigates the role of Auts2a in zebrafish escape behavior, finding that mutations lead to neuronal excitability issues and behavioral variability.