Exploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis
Zainab Edoo, Astrid Lenne, Camille Grosse, Marie Devaere, Marion Michel, Guillaume Caron, Ernesto Anoz‐Carbonell, Kamel Djaout, Rosangela Frita, Cyril Gaudin, Line Hofmann, Sophie Lecher, Véronique Mégalizzi, Alessia Michelotti, David Rengel, , Alain R. Baulard
This paper identifies BVL3572S as a compound that inhibits HisC and AlaA in Mtb, causing metabolic stress and showing synergy with existing drugs.
Cell chemical biology · Aug 1, 2026Peer-reviewedMicrobiology