Alain R. Baulard

DDU384: A new preclinical candidate for the treatment of Tuberculosis

This paper identifies DDU384, a new compound with potent in vivo efficacy against tuberculosis in murine models, showing potential to improve current treatment options.

Exploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

This paper identifies BVL3572S as a compound that inhibits HisC and AlaA in Mtb, causing metabolic stress and showing synergy with existing drugs.

Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genes

The paper identifies alanine's role in linking trans-translation to WhiB7-mediated antibiotic resistance and recalcitrance in Mycobacterium smegmatis.

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification

This study investigates the mechanism of action of pyrazinamide (PZA) in Mycobacterium tuberculosis, showing it kills bacteria by acidifying cytosol via pH-driven weak-acid permeation, independent of PanD and pantothenate levels.