Author

Christophe Guilhot

Centre National de la Recherche ScientifiqueORCID 0000-0002-8052-4685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Alain R. BaulardiD· 2 shared Rudy AntoineiD· 2 shared Alessia MichelottiiD· 1 shared Andrea MajstorovićiD· 1 shared António PeixotoiD· 1 shared Astrid Lenne· 1 shared Camille GrosseiD· 1 shared Carmen López‐IglesiasiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

Alain R. BaulardORCID

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3 papers

Recent·Most cited

Exploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

Zainab Edoo, Astrid Lenne, Camille Grosse, Marie Devaere, Marion Michel, Guillaume Caron, Ernesto Anoz‐Carbonell, Kamel Djaout, Rosangela Frita, Cyril Gaudin, Line Hofmann, Sophie Lecher, Véronique Mégalizzi, Alessia Michelotti, David Rengel, , Alain R. Baulard

This paper identifies BVL3572S as a compound that inhibits HisC and AlaA in Mtb, causing metabolic stress and showing synergy with existing drugs.

Cell chemical biology · Aug 1, 2026Peer-reviewedMicrobiology

Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genes

Andrea Majstorović, Hélène Botella, Sarah M. Schrader, Yaroslav Lavrynchuk, Xinguo Chen, Enkai Jin, Jason Taslim, Rudy Antoine, Alain R. Baulard, Christophe Guilhot, Przemysław Płociński, Sandra L. Wolin, Julien Vaubourgeix

The paper identifies alanine's role in linking trans-translation to WhiB7-mediated antibiotic resistance and recalcitrance in Mycobacterium smegmatis.

bioRxiv · Oct 10, 2025 · PreprintMicrobiology

Mycobacteria-host interactions in human bronchiolar airway organoids

Nino Iakobachvili, Stephen Adonai Leon‐Icaza, Kèvin Knoops, Norman Sachs, Serge Mazères, Roxane Siméone, António Peixoto, Célia Bernard, M. Murris‐Espin, Julien Mazières, Kaymeuang Cam, Christian Chalut, Christophe Guilhot, Carmen López‐Iglesias, Raimond B. G. Ravelli, , Peter J. Peters

This study uses human airway organoids to model tuberculosis infection, showing mycobacteria infect epithelial cells with low efficiency and the organoid microenvironment controls but does not eliminate the pathogen.

Molecular Microbiology · Oct 5, 2021Peer-reviewedSystems Biology