Guillaume Caron

Defective synapto-nuclear signaling contributes to motoneuron vulnerability in SOD1-ALS

The paper investigates synapto-nuclear signaling defects in mSOD1 mice and shows that restoring cAMP/PKA signaling mitigates pathology in motoneurons.

Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice

This study shows that β-adrenergic receptors regulate spinal motoneuron excitability through homeostatic feedback in both wild-type and presymptomatic SOD1 mice.

KCC2 Enhancers Normalize Reflex Responses and Improve Locomotor Function after Chronic Spinal Cord Injury

This study shows that enhancing KCC2 activity normalizes reflex responses and improves locomotor function in chronic spinal cord injury rats.

Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration

The paper investigates how spinal microcircuits adapt in a mouse model of motoneuron degeneration, finding specific multiphasic homeostatic compensations that preserve force output.

Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic SCI

This study shows that increasing KCC2 activity pharmacologically reduces spasticity and hyperreflexia after chronic SCI, similar to the effects of exercise.

Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step-training in the decerebrated rat

This study shows that chronic spinal cord injury reduces presynaptic inhibition via PBSt afferents, but step-training restores it through activity-dependent plasticity in decerebrated rats.