Pregnenolone and AEF0117 block cannabinoid-induced hyperlocomotion through GSK3β signaling at striatopallidal neurons
Giovanni Tomaselli, Luigi Bellocchio, Pierre‐Louis Raux, Valérie Roullot, Arnau Busquets-García, Valérie Lalanne, Yamuna Mariani, Adeline Cathala, Marion Zanese, Astrid Cannich, Agnès Grel, Doriane Gisquet, Miguel Mondésir, Mathilde Metna‐Laurent, Guillaume Drutel, , Monique Vallée
This study shows that pregnenolone and AEF0117 block THC-induced hyperlocomotion by inhibiting CB1R-mediated GSK3β signaling in striatopallidal neurons.
bioRxiv · Mar 7, 2025 · PreprintNeuroscience