Luigi Bellocchio

This study shows that deleting Shank3 in glutamatergic neurons of the anterior insular cortex causes autism-like behaviors and circuit dysfunction in mice.

This study shows that an obesogenic diet impairs memory consolidation in mice via the hippocampal endocannabinoid system and mTOR pathway, which can be reversed by CB1R blockade or mTOR inhibition.

This study shows that pregnenolone and AEF0117 block THC-induced hyperlocomotion by inhibiting CB1R-mediated GSK3β signaling in striatopallidal neurons.

This study identifies CB1R overactivation as a driver of CRBN deficiency-linked ARNSID and suggests CB1R blockade as a potential therapy.

This study investigates the role of CB1 receptors in glial cells during neuromuscular junction repair after nerve injury, finding that their blockade accelerates denervation and delays reinnervation.

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.

This study identifies CB1 receptor-mediated circuit mechanisms in the insula that regulate water intake, showing distinct roles of anterior and posterior insula projections to the basolateral amygdala.

The paper identifies functional heterogeneity in POMC neurons and shows that mTORC1 signaling regulates their distinct roles in feeding behavior.

The paper generates and characterizes a mutant mouse lacking mitochondrial-associated CB1 receptors to study their role in brain function and drug effects.

The paper identifies a circuit involving endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala that promotes water intake.

This study identifies a specific subclass of hippocampal interneurons that regulate recognition memory consolidation through CB1 receptor signaling and GABAergic inhibition.