Giovanni Marsicano

The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

This study shows that astrocytic PI3Kα supports synaptic plasticity and cognitive function by regulating serine metabolism and D-serine levels necessary for NMDA receptor activation during long-term potentiation.

This study investigates how endocannabinoid-dopamine interactions in the hippocampus mediate incidental associations, showing that CB1 receptors in D1-receptor-expressing cells are critical for IA formation.

This study shows that deleting Shank3 in glutamatergic neurons of the anterior insular cortex causes autism-like behaviors and circuit dysfunction in mice.

This study shows that an obesogenic diet impairs memory consolidation in mice via the hippocampal endocannabinoid system and mTOR pathway, which can be reversed by CB1R blockade or mTOR inhibition.

This study shows that astrocyte CB1R signaling promotes inflammation in MS by disrupting the blood-brain barrier and reducing BBB function.

This study shows that CB1 receptors in neurons and astrocytes differentially affect spatial navigation and memory in male and female mice.

This study shows that pregnenolone and AEF0117 block THC-induced hyperlocomotion by inhibiting CB1R-mediated GSK3β signaling in striatopallidal neurons.

This paper demonstrates myside confirmation bias-like behavior in mice during rule revision tasks, showing it emerges through deliberative processes rather than heuristic responses.

This study identifies aberrant astrocytic calcium signaling in MS models as a contributor to synaptic plasticity impairment and gray matter pathology.

This study investigates the role of CB1 receptors in glial cells during neuromuscular junction repair after nerve injury, finding that their blockade accelerates denervation and delays reinnervation.

The paper shows that two endocannabinoids, 2-AG and AEA, signal to different cell types (neurons and astrocytes), inducing distinct synaptic regulation mechanisms.

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.

The paper reveals column- and layer-specific astrocyte-mediated non-synaptic communication between cortical neurons through CB1R activation and ATP/adenosine release.

This study identifies CB1 receptor-mediated circuit mechanisms in the insula that regulate water intake, showing distinct roles of anterior and posterior insula projections to the basolateral amygdala.

The paper identifies functional heterogeneity in POMC neurons and shows that mTORC1 signaling regulates their distinct roles in feeding behavior.

The paper identifies a differential role of CB1-expressing interneurons in controlling pyramidal neuron activity in primary and secondary visual cortical areas through distinct endocannabinoid mechanisms.

The paper shows that mtCB1 receptor activation in astrocytes regulates calcium transfer from ER to mitochondria, influencing synaptic integration and plasticity.

The paper generates and characterizes a mutant mouse lacking mitochondrial-associated CB1 receptors to study their role in brain function and drug effects.

The paper identifies a circuit involving endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala that promotes water intake.

This study identifies a specific subclass of hippocampal interneurons that regulate recognition memory consolidation through CB1 receptor signaling and GABAergic inhibition.