Astrid Cannich

Ventromedial striatal GABAergic interneurons sex-dependently gate cost-benefit choices between food and exercise

Pregnenolone and AEF0117 block cannabinoid-induced hyperlocomotion through GSK3β signaling at striatopallidal neurons

This study shows that pregnenolone and AEF0117 block THC-induced hyperlocomotion by inhibiting CB1R-mediated GSK3β signaling in striatopallidal neurons.

A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.

Cannabinoids regulate an insula circuit controlling water intake

This study identifies CB1 receptor-mediated circuit mechanisms in the insula that regulate water intake, showing distinct roles of anterior and posterior insula projections to the basolateral amygdala.

POMC neurons functional heterogeneity relies on mTORC1 signaling

The paper identifies functional heterogeneity in POMC neurons and shows that mTORC1 signaling regulates their distinct roles in feeding behavior.

Astroglial calcium transfer from endoplasmic reticulum to mitochondria determines synaptic integration

The paper shows that mtCB1 receptor activation in astrocytes regulates calcium transfer from ER to mitochondria, influencing synaptic integration and plasticity.

Top-down control of water intake by the endocannabinoid system

The paper identifies a circuit involving endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala that promotes water intake.

Specific hippocampal interneurons shape consolidation of recognition memory

This study identifies a specific subclass of hippocampal interneurons that regulate recognition memory consolidation through CB1 receptor signaling and GABAergic inhibition.