MYCN-induced lineage infidelity initiates SHH medulloblastoma-like tumors outside the canonical lineage of origin
Lauranne Bouteille, William Fargues, Paul de Boissier, Guillaume Girard, Mehdi Saadaoui, Cédric Maurange
The paper shows MYCN overexpression in avian embryos leads to SHH medulloblastoma-like tumors through a three-step process involving ATOH1+ progenitors and PAX6 reprogramming.
bioRxiv · Aug 10, 2026 · PreprintCancer Biology