Author

Guillermo A. de Paz Linares

University of Toronto

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Cell Biology· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

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Blayne Amir SayediD· 1 shared Jan MossemanniD· 1 shared Spencer A. FreemaniD· 1 shared

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2025-2025 · peak 1/yr

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Blayne Amir SayedORCID

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1 paper

Recent·Most cited

Cell BiologyMolecular Biology of the CellPeer-reviewedMay 15, 2025

The scaffolding and activation of NLRP3 on acidic vesicles depends on their biophysical properties and is independent of intermediate filaments

Guillermo A. de Paz Linares, Jan Mossemann, Blayne Amir Sayed, Spencer A. Freeman

This study shows NLRP3 inflammasome activation depends on biophysical properties of acidic vesicles, not intermediate filaments, in vimentin knockout macrophages.

2 citations

mouseexperimental assay

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