Spencer A. Freeman

This study identifies NINJ1 as a mediator of hepatic ischemia-reperfusion injury, showing its role in cell death and inflammation, and suggests it as a therapeutic target.

This study identifies TMEM63A as a mechanosensitive channel in lysosomes that relieves membrane tension by expelling cations and osmoticants, preventing rupture and cell death.

This study identifies phosphatidylethanolamine (PE) as a phagocytic ligand recognized by CD300 receptors, facilitating the uptake of apoptotic cells and microbial extracellular vesicles.

This study shows NLRP3 inflammasome activation depends on biophysical properties of acidic vesicles, not intermediate filaments, in vimentin knockout macrophages.

This study shows that TMEM16F-mediated lipid scrambling drives the formation and release of apoptotic-like vesicles without affecting cytosolic calcium or the cytoskeleton.

The paper identifies calcium-driven lipid scrambling as the mechanism activating NINJ1-mediated plasma membrane rupture during lytic cell death.

This study shows that reactive oxygen species (ROS) from IgG-opsonized targets suppress phagocyte surveillance by oxidizing cytoskeletal regulators, leading to cell compaction and podosome disassembly.