Genotoxic chemotherapy impedes complement dependent cytotoxicity via Chk1-mediated CD59 regulation
Allison S. Y. Chan, Akshaya Anbuselvan, Patrick William Jaynes, Charmaine Ong, Michał Marek Hoppe, Wai Khang Yong, Vartika Khanchandani, Jie Min Lee, Nurulhuda Binte Mustafa, Irfan Azaman, Phuong Mai Hoang, Guo Hong, Wee Joo Chng, Mark Steven Cragg, Dennis Kappei, , Anand Devaprasath D. Jeyasekharan
This study shows genotoxic chemotherapy increases CD59 expression, reducing complement-dependent cytotoxicity and rituximab efficacy in DLBCL via Chk1-mediated regulation.
bioRxiv · Feb 17, 2025 · PreprintCancer Biology