Dennis Kappei

HOT1 functions as a homodimer to promote ALT-permissive chromatin

This study shows HOT1 functions as a homodimer to maintain an ALT-permissive chromatin state at telomeres.

Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interaction.

This study identifies IQGAP3 as a Wnt signaling mediator that stabilizes β-catenin by disrupting Axin1-CK1α interaction and is itself regulated by Wnt signaling.

Genotoxic chemotherapy impedes complement dependent cytotoxicity via Chk1-mediated CD59 regulation

This study shows genotoxic chemotherapy increases CD59 expression, reducing complement-dependent cytotoxicity and rituximab efficacy in DLBCL via Chk1-mediated regulation.

The TARZN complex binds de novo enhancer mutations and promotes oncogenic expression in T-ALL

The paper identifies the TARZN complex, which binds de novo enhancer mutations and promotes TAL1 overexpression in T-ALL through RNA methylation.

Formation and recycling of an active epigenetic mark mediated by cell cycle-specific RNAs

The paper shows that cell cycle-specific long noncoding RNAs regulate the establishment and recycling of the acetylated histone H2A.Z epigenetic mark.