VEGFA-Positive Macrophages Regulate Aqueous Humor Outflow in Aged Mice and Humans
Naoki Kiyota, Yalu Zhou, Dilip K. Deb, Guohui Ren, Tuncer Onay, Ester Reina‐Torres, Hoi‐Lam Li, Constance E. Runyan, Robert S. Feder, Hyunjoo Jean Lee, Darryl R. Overby, Haiyan Gong, G. R. Scott Budinger, Benjamin R. Thomson, Susan E. Quaggin
This study identifies VEGFA-producing macrophages around Schlemm's canal as a compensatory mechanism maintaining aqueous humor outflow during aging and vascular stress, suggesting TIE2 activation as a therapeutic target.
bioRxiv · Sep 11, 2026 · PreprintPhysiology