Darryl R. Overby

This study identifies VEGFA-producing macrophages around Schlemm's canal as a compensatory mechanism maintaining aqueous humor outflow during aging and vascular stress, suggesting TIE2 activation as a therapeutic target.

This study shows that endothelial cell stiffness and type influence biomechanically-induced transcellular pore formation in Schlemms canal cells.

This study identifies KALRN and TMCO1 as interdependent regulators of trabecular meshwork homeostasis and intraocular pressure, linking ER and calcium homeostasis to glaucoma pathogenesis.

This study shows corticosteroids increase intraocular pressure by suppressing TREK-1 channels in trabecular meshwork cells, leading to ocular hypertension, which can be counteracted by TREK-1 agonists.

This study shows TRPV4 modulates substrate stiffness sensing and transcellular pore formation in Schlemm's canal cells, with implications for glaucoma treatment.