V. I. Zarnitsyna

Differentiation marker-negative CD4+ T cells persist after yellow fever virus vaccination and contribute to durable memory

The paper identifies TMN CD4+ T cells that persist after YFV vaccination and contribute to long-term immunological memory.

Modeling suggests that multiple immunizations or infections will reveal the benefits of updating SARS-CoV-2 vaccines

The paper models how updating SARS-CoV-2 vaccines could provide benefits through qualitatively different humoral immunity, suggesting a two-dose strategy for vaccine updates and high-risk vaccination.

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

Durability of immune responses to the BNT162b2 mRNA vaccine

This study shows that antibody and T cell responses to the BNT162b2 vaccine wane significantly at 6 months, suggesting a potential need for a third booster dose.

Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

This study uses mathematical models to show that memory CD8 T cells decline following a power law, with division rates stabilizing and death rates declining slowly over decades.

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

This study examines how pre-existing T cell characteristics influence the immune response to a yellow fever vaccine, finding that memory T cells and rare populations shape post-vaccination responses.

Quantifying memory CD8 T cell-mediated immune pressure on influenza A virus infection in vivo

This study quantifies the immune pressure exerted by memory CD8 T cells on influenza A virus in vivo, showing that an epitope-escaping mutation confers a fitness advantage under certain immune conditions.

Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?

This paper investigates why CD8 T cell epitopes of influenza A virus are conserved, proposing mechanisms that explain their persistence despite potential escape variants.