R. Antia

Memory CD4 T cell subset organization in the female reproductive tract is regulated via the menstrual cycle through CCR5 signaling

Modeling suggests that multiple immunizations or infections will reveal the benefits of updating SARS-CoV-2 vaccines

The paper models how updating SARS-CoV-2 vaccines could provide benefits through qualitatively different humoral immunity, suggesting a two-dose strategy for vaccine updates and high-risk vaccination.

Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

This study uses mathematical models to show that memory CD8 T cells decline following a power law, with division rates stabilizing and death rates declining slowly over decades.

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

This study examines how pre-existing T cell characteristics influence the immune response to a yellow fever vaccine, finding that memory T cells and rare populations shape post-vaccination responses.

Using directed attenuation to enhance vaccine immunity

The paper uses mathematical models to show that directed attenuation of viral immune evasion pathways can reduce viral growth without compromising immunity, potentially enhancing vaccine effectiveness.

Quantifying memory CD8 T cell-mediated immune pressure on influenza A virus infection in vivo

This study quantifies the immune pressure exerted by memory CD8 T cells on influenza A virus in vivo, showing that an epitope-escaping mutation confers a fitness advantage under certain immune conditions.

Recombinant vector vaccines and within-host evolution

This paper models within-host evolution of recombinant vector vaccines and finds that vaccine efficacy can be reduced by transgene loss, but this can be mitigated by increasing inoculum size or purity.

A dynamical motif comprising the interactions between antigens and CD8 T cells may underlie the outcomes of viral infections

The paper identifies a dynamical motif of antigen-CD8 T cell interactions that determines outcomes of viral infections and explains various experimental observations.

Incomplete influenza A virus genomes are abundant but readily complemented during spatially structured viral spread

The paper quantifies incomplete influenza A virus genomes (IVGs) and shows they require complementation for replication, but spatial structure facilitates this process, supporting viral spread but not transmission.

Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?

This paper investigates why CD8 T cell epitopes of influenza A virus are conserved, proposing mechanisms that explain their persistence despite potential escape variants.