Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis
H. N. Nguyen, Y. Jeong, Y. Kim, Y. H. Kim, H. Athar, P. J. Castaldi, C. P. Hersh, R. F. Padera, L. M. Sholl, M. Vivero, N. S. Sharma, J. Yun, L. T. Merriam, K. Yuan, E. Y. Kim, M. B. Brenner
This study identifies LIFR as a master amplifier of fibroblast activation in IPF, showing that blocking LIFR reduces fibrosis in ex vivo tissue.
bioRxiv · May 21, 2024Cell Biology