N. S. Sharma

Dynamic model of bovine brucellosis to investigate control strategies in endemic settings

The paper develops a stochastic, age-structured model to evaluate brucellosis control strategies in dairy cattle herds in India, finding that vaccination of replacement calves and long-term commitment to vaccination are key for effective control.

Single cell transcriptome mapping identifies a local innate B cell population driving local antibody production and chronic rejection after lung transplantation

The paper identifies a local innate B cell population that drives antibody production and chronic rejection in lung transplants using single-cell transcriptomics.

Stroma secreted IL6 selects for stem-like population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways

This study shows that stromal IL6 promotes stem-like cells and metabolic reprogramming in pancreatic tumors, creating an immune-evasive microenvironment that can be targeted to improve checkpoint inhibitor therapy.

Hypoxia driven oncometabolite L-2HG maintains "stemness"-differentiation balance and facilitates immune suppression in pancreatic cancer

This study shows hypoxia drives L-2HG production in pancreatic tumors, maintaining stemness-differentiation balance and promoting immune suppression, with LDH inhibition reversing these effects.

Targeting tumor intrinsic metabolic node in pancreatic cancer causes tumor regression, remodels extracellular matrix and sensitizes to anti-PD1 therapy.

This study shows that targeting the HBP metabolic node in pancreatic cancer with DON reduces tumor growth, remodels the ECM, and enhances response to anti-PD1 therapy.

Long non-coding RNA GAS5 acts as proliferation brakes in CD133+ cells responsible for tumor recurrence

This study shows GAS5 regulates quiescence and growth arrest in CD133+ cells, which drive tumor recurrence in pancreatic cancer by inhibiting cell cycle progression and altering metabolic pathways.