Y. H. Kim

Structure of recombinant formate dehydrogenase from Methylobacterium extorquens (MeFDH1)

The paper determines the structure of recombinant formate dehydrogenase from Methylobacterium extorquens using cryo-electron microscopy, revealing a noncanonical active site and dynamic structural features.

Selective inhibition of interleukin-2 inducible T cell kinase (ITK) enhances anti-tumor immunity in association with Th1-skewing, cytotoxic T cell activation, and reduced T cell exhaustion

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

Resilient CD8+ T cells maintain a high cytotoxic capacity by balancing ROS via ME1 upregulation

This paper identifies CX3CR1+ CD8+ T cells with low mitochondrial membrane potential as functionally resilient, showing high cytotoxicity and reduced ROS through ME1 upregulation, which enhances their anti-tumor activity.

Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

This paper introduces magneto-gas vesicles (MGVs) for non-invasive in vivo imaging of tissue mechanics, showing improved sensitivity and resolution compared to existing methods.

Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

This study compares the infectivity of SARS-CoV-2 variants in human alveolar cells, finding Omicron (BA.1) to be 3-5-fold more infectious than other variants at early infection.

Size-dependent protein segregation creates a spatial switch for Notch signaling and function

The paper shows that spatial constraints at cadherin-based adherens junctions regulate Notch cleavage by gamma-secretase, affecting signaling and cell differentiation.

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses

This paper develops a herpesvirus vaccine by deleting immune evasion genes to enhance immunogenicity and safety, showing durable protection against latency in a mouse model.

6-O-galloylsalidroside, an active ingredient from Acer tegmentosum, ameliorates alcoholic steatosis and liver injury in a mouse model of chronic ethanol consumption

This study investigates the effect of 6-O-galloylsalidroside on alcoholic steatosis and liver injury in mice, finding it reduces lipid accumulation and liver damage.

Dose assessment in dental cone beam computed tomography: comparison of optically stimulated luminescence dosimetry with the Monte Carlo method

This study compares optically stimulated luminescence dosimetry with Monte Carlo simulation to assess patient dose in dental cone beam computed tomography across different examination modes.