Author

H. B. Fraser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. L. Starr· 2 shared B. Zhao· 2 shared D. Gokhman· 2 shared B. Wang· 1 shared C. T. Miller· 1 shared C. V. Weiss· 1 shared D. A. Petrov· 1 shared F. Inoue· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersEvolutionary Biology

A. L. Starr

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Author profile →

5 papers

Recent·Most cited

Cell type-specific cis-regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cells

B. Wang, A. L. Starr, H. B. Fraser

The paper identifies cell type-specific cis-regulatory divergence in gene expression and chromatin accessibility using human-chimpanzee hybrid cells across six cell types.

bioRxiv · May 22, 2023 · PreprintEvolutionary Biology

Evolution of spatial and temporal cis-regulatory divergence between marine and freshwater sticklebacks

K. L. Mack, T. A. Square, B. Zhao, C. T. Miller, H. B. Fraser

This study identifies cis-regulatory divergence between marine and freshwater sticklebacks using allele-specific expression in hybrids, showing widespread regulatory changes and lineage-specific selection.

bioRxiv · Sep 30, 2022 · PreprintEvolutionary Biology

Accounting for cis-regulatory constraint prioritizes genes likely to affect species-specific traits

A. L. Starr, D. Gokhman, H. B. Fraser

The paper identifies genes with constrained cis-regulation within species but divergent regulation between species using allele-specific RNA-seq data from human-chimpanzee hybrids.

bioRxiv · Mar 29, 2022Evolutionary Biology

Bacterial retrons enable precise gene editing in human cells

B. Zhao, S.-A. A. Chen, J. Lee, H. B. Fraser

This study shows retrons can generate donor DNA for HDR gene editing in human cells, achieving up to 11.3% HDR efficiency when combined with CRISPR-Cas9.

The CRISPR Journal · Feb 22, 2022Peer-reviewedBioengineering

The cis-regulatory effects of modern human-specific variants

C. V. Weiss, L. Harshman, F. Inoue, H. B. Fraser, D. A. Petrov, N. Ahituv, D. Gokhman

The paper investigates the regulatory effects of modern human-specific variants using a massively parallel reporter assay in three cell types, finding 1,791 active sequences and 407 driving differential expression.

bioRxiv · Oct 7, 2020Evolutionary Biology