LUBAC is required for RIG-I sensing of RNA viruses
H. C. Teague, C. Lefevre, E. Rieser, D. de Miguel, D. Patricio, M. Oliveira, D. S. Mansur, N. Irigoyen, H. Walczak, B. J. Ferguson
This study shows that LUBAC components HOIP and HOIL-1 are required for RIG-I sensing of RNA viruses, while SHARPIN is not, highlighting LUBAC's role in antiviral immunity.
bioRxiv · Feb 24, 2022Immunology