Author

N. Irigoyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Lefevre· 3 shared A. M. Dinan· 2 shared B. J. Ferguson· 2 shared D. S. Mansur· 2 shared G. M. Cook· 2 shared H. Stewart· 2 shared I. Brierley· 2 shared K. Brown· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

C. Lefevre

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Spatial proteomics identifies a novel CRTC-dependent viral sensing pathway that stimulates production of Interleukin-11

B. J. Ravenhill, M. Oliveira, G. Wood, Y. Di, C. Davies, Y. Lu, R. Antrobus, G. Elliott, N. Irigoyen, D. J. Hughes, P. Lyons, B. Y. Chung, G. Borner, M. P. Weekes

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

bioRxiv · Apr 4, 2024 · PreprintImmunology

Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism

C. Lefevre, G. M. Cook, A. M. Dinan, S. Torii, H. Stewart, G. Gibbons, A. S. Nicholson, L. Echavarria-Consuegra, L. W. Meredith, V. Lulla, J. C. Kenyon, I. G. Goodfellow, J. E. Deane, S. C. Graham, A. Lakatos, , N. Irigoyen

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

bioRxiv · Apr 20, 2023 · PreprintMicrobiology

LUBAC is required for RIG-I sensing of RNA viruses

H. C. Teague, C. Lefevre, E. Rieser, D. de Miguel, D. Patricio, M. Oliveira, D. S. Mansur, N. Irigoyen, H. Walczak, B. J. Ferguson

This study shows that LUBAC components HOIP and HOIL-1 are required for RIG-I sensing of RNA viruses, while SHARPIN is not, highlighting LUBAC's role in antiviral immunity.

bioRxiv · Feb 24, 2022Immunology

PKR-mediated Stress Response Enhances Dengue and Zika Virus Replication

T. Ricciardi-Jorge, E. Lummertz da Rocha, E. Gonzalez-Kozlova, G. F. Rodrigues-Luiz, B. J. Ferguson, T. Sweeney, N. Irigoyen, D. S. Mansur

This study shows that PKR-mediated stress response enhances Dengue and Zika virus replication by co-opting the integrated stress response to promote viral mRNA translation.

bioRxiv · Apr 8, 2021Immunology

Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infection

L. Echavarria-Consuegra, G. M. Cook, I. Busnadiego, C. Lefevre, S. Keep, K. Brown, N. Doyle, G. Dowgier, K. Franaszek, N. A. Moore, S. G. Siddell, E. Bickerton, B. G. Hale, A. E. Firth, I. Brierley, N. Irigoyen

This paper investigates the unfolded protein response (UPR) in coronavirus infection and shows that pharmacological inhibition of the UPR significantly reduces viral replication.

bioRxiv · Mar 19, 2021Microbiology

The transcriptional and translational landscape of equine torovirus

H. Stewart, K. Brown, A. M. Dinan, N. Irigoyen, E. J. Snijder, A. Firth

This study analyzes the transcription and translation of equine torovirus using RNA-seq and Ribo-seq, identifying novel open reading frames and subgenomic RNA synthesis mechanisms.

bioRxiv · Apr 7, 2018Microbiology