M. Oliveira

Spatial proteomics identifies a novel CRTC-dependent viral sensing pathway that stimulates production of Interleukin-11

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

Activation of innate immunity selectively compromises mitochondrial complex I, proline oxidation and flight activity in the major arbovirus vector Aedes aegypti

This study shows that activating innate immunity in Aedes aegypti reduces mitochondrial complex I activity, proline oxidation, and flight activity, indicating a trade-off between immunity and dispersal.

Advancing GABA-edited MRS Research through a Reconstruction Challenge

This paper presents a benchmark challenge to compare machine learning models for GABA-edited MRS reconstruction using reduced transients, finding that deep learning models achieve comparable metrics to conventional methods.

Mechanisms of type I interferon production by chicken TLR21

This study investigates how chicken TLR21 triggers type I interferon production in macrophages, revealing conserved signaling pathways with mammalian TLR9.

The heme exporter FLVCR regulates mitochondrial biogenesis and redox balance in the hematophagous insect Rhodnius prolixus

This study identifies FLVCR as a heme exporter in Rhodnius prolixus, showing its role in heme/iron metabolism and redox balance through gene expression and metabolic changes.

A Dual Color Pax7 and Myf5 In Vivo Reporter to Investigate Muscle Stem Cell Heterogeneity in Regeneration and Aging

The paper develops a dual color reporter system to study muscle stem cell heterogeneity, identifying a quiescent subpopulation that declines with age.

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

This study shows DNA-PK is essential for STING-dependent IFN-I responses to exogenous DNA and DNA virus infection in human cells.

Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1

This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.

LUBAC is required for RIG-I sensing of RNA viruses

This study shows that LUBAC components HOIP and HOIL-1 are required for RIG-I sensing of RNA viruses, while SHARPIN is not, highlighting LUBAC's role in antiviral immunity.

Adaptive reprogramming during early seed germination requires temporarily enhanced fermentation a critical role for alternative oxidase (AOX) regulation that concerns also microbiota effectiveness

The paper investigates the role of alternative oxidase (AOX) and sucrose in early seed germination, showing that AOX regulation and microbial interactions are critical for metabolic adjustment and germination efficiency.

ROS/RNS balancing, aerobic fermentation regulation and cell cycle control a complex early trait ('CoV-MAC-TED') for combating SARS-CoV-2-induced cell reprogramming

The paper identifies a complex trait, CoV-MAC-TED, linked to SARS-CoV-2-induced cell reprogramming through unbalanced ROS/RNS levels and aerobic fermentation.

Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.

This paper shows that muscle-secreted neurturin (NRTN) couples muscle oxidative metabolism with slow motor neuron identity, improving exercise performance and motor coordination.

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications

The paper investigates iron metabolism in AML, finding that AML causes iron redistribution through erythroblast loss, leading to high TSAT and improved survival.

Chicken cGAS senses fowlpox virus infection and regulates macrophage effector function

This study shows that chicken cGAS detects fowlpox virus DNA, triggering type-I interferon production and regulating macrophage effector functions like MHC-II expression.

Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion

This study develops a method to assess mitochondrial function in murine white adipose tissue using mechanical permeabilization and lipid depletion, finding higher respiratory capacity in female tissue.

An investigation of PS-b-PEO polymersomes for the oral treatment and diagnosis of hyperammonemia

This paper investigates polymersomes for oral treatment and diagnosis of hyperammonemia, finding they do not reduce ammonia levels in rats but can detect ammonia via pH changes.

Mitochondrial glycerol phosphate oxidation is modulated by adenylates through allosteric regulation of cytochrome c oxidase activity in mosquito flight muscle.

Processing cookies formulated with goat cream enriched with conjugated linoleic acid

This study developed cookies using goat cream enriched with CLA and found that CGCLA cookies had higher CLA levels and comparable consumer acceptance to other formulations.