This study examines how varying doses of bacteria and arboviruses affect Aedes aegypti survival, finding that oral bacterial infection enhances defensive capacity and that Zika virus causes greater mortality than Dengue virus.

bioRxiv · Sep 29, 2022 · PreprintMicrobiology

LUBAC is required for RIG-I sensing of RNA viruses

H. C. Teague, C. Lefevre, E. Rieser, D. de Miguel, D. Patricio, M. Oliveira, D. S. Mansur, N. Irigoyen, H. Walczak, B. J. Ferguson

This study shows that LUBAC components HOIP and HOIL-1 are required for RIG-I sensing of RNA viruses, while SHARPIN is not, highlighting LUBAC's role in antiviral immunity.

bioRxiv · Feb 24, 2022Immunology

PKR-mediated Stress Response Enhances Dengue and Zika Virus Replication

T. Ricciardi-Jorge, E. Lummertz da Rocha, E. Gonzalez-Kozlova, G. F. Rodrigues-Luiz, B. J. Ferguson, T. Sweeney, N. Irigoyen, D. S. Mansur

This study shows that PKR-mediated stress response enhances Dengue and Zika virus replication by co-opting the integrated stress response to promote viral mRNA translation.

bioRxiv · Apr 8, 2021Immunology

Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19

R. O. Formiga, F. C. Amaral, C. F. Souza, D. A. G. B. Mendes, C. W. S. Wanderley, C. B. Lorenzini, A. A. Santos, J. Antonia, L. F. Faria, C. C. Natale, N. M. Paula, P. C. S. Silva, F. R. Fonseca, L. Aires, N. Heck, , F. Spiller

This paper shows neuraminidase inhibitors reduce neutrophil overactivation in sepsis and COVID-19 by inhibiting sialic acid release and ROS production.

bioRxiv · Nov 12, 2020 · PreprintImmunology

An evolutionary recent IFN-IL-6-CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

M. Delgobo, D. A. Mendes, E. Kozlova, E. L. Rocha, G. F. Rodrigues-Luiz, L. Mascarin, G. Dias, D. O. Patricio, T. Dierckx, M. A. Bicca, G. Breton, Y. K. T. Menezes, M. Starick, D. Rovaris, J. D. Moral, , A. Bafica

bioRxiv · Sep 20, 2019Immunology

Vasculature-associated adipose tissue macrophages dynamically adapt to inflammatory and metabolic challenges

H. Moura Silva, A. Bafica, G. F. Rodrigues-Luiz, J. Chi, P. d. A. Santos, B. Sgarbi Reis, D. Hoytema van Konijnenburg, A. Crane, R. D. N. Arifa, P. Martin, D. A. Gasparin Bueno Mendes, D. S. Mansur, V. Torres, K. Cadwell, P. Cohen, , J. J. Lafaille

The paper identifies vasculature-associated adipose tissue macrophages (VAMs) and shows how they adapt to metabolic and inflammatory challenges in epididymal white adipose tissue.

bioRxiv · May 31, 2018Immunology

IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.

R. C. Fleith, H. V. Mears, E. Emmott, S. C. Graham, D. S. Mansur, T. R. Sweeney

This study identifies how IFIT3 and IFIT2 enhance IFIT1's ability to inhibit translation by stabilizing its binding to non-self RNA.

bioRxiv · Feb 8, 2018Immunology

ISG15 induces IL-10 production in human monocytes and is a biomarker of disease severity during active tuberculosis

P. F. dos Santos, J. Van Weyenbergh, M. Delgobo, D. d. O. Patricio, B. J. Ferguson, R. GUABIRABA, T. Dierckx, S. M. M. MENEZES, A. Bafica, D. S. Mansur

The paper shows ISG15 induces IL-10 in human monocytes and correlates with TB disease severity.

bioRxiv · Aug 2, 2017Immunology