Patched regulates lipid homeostasis by controlling cellular cholesterol levels
C. E. Cadena Del Castillo, J. T. Hannich, A. Kaech, H. Chiyoda, M. Fukuyama, N. J. Færgeman, H. Riezman, A. Spang
This study identifies PTC-3 as a cholesterol transporter in C. elegans, showing that its loss causes cholesterol accumulation, ER defects, and lipid metabolism issues, which are rescued by reducing dietary cholesterol.
bioRxiv · Oct 23, 2019Cell Biology