Author

J. T. Hannich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

H. Riezman· 2 shared A. G. Haribowo· 1 shared A. H. Michel· 1 shared A. Kaech· 1 shared A. Rukavina· 1 shared A. Spang· 1 shared B. Kornmann· 1 shared C. E. Cadena Del Castillo· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

H. Riezman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

M. Cigler, H. Imrichova, F. Frommelt, L. Depta, A. Rukavina, C. Kagiou, J. T. Hannich, C. Mayor-Ruiz, G. Superti-Furga, S. Sievers, L. Laraia, H. Waldmann, G. E. Winter

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

bioRxiv · Mar 15, 2023 · PreprintPharmacology & Toxicology

Patched regulates lipid homeostasis by controlling cellular cholesterol levels

C. E. Cadena Del Castillo, J. T. Hannich, A. Kaech, H. Chiyoda, M. Fukuyama, N. J. Færgeman, H. Riezman, A. Spang

This study identifies PTC-3 as a cholesterol transporter in C. elegans, showing that its loss causes cholesterol accumulation, ER defects, and lipid metabolism issues, which are rescued by reducing dietary cholesterol.

bioRxiv · Oct 23, 2019Cell Biology

Cytotoxicity of 1-deoxysphingolipid Unraveled by Genome-wide Genetic Screens and Lipidomics

A. G. Haribowo, J. T. Hannich, A. H. Michel, M. Megyeri, M. Schuldiner, B. Kornmann, H. Riezman

This study identifies cytotoxic effects of 1-deoxysphingolipid species and reveals mechanisms linking their accumulation to HSAN IA/C pathology through genetic screens and lipidomics.

bioRxiv · Jun 3, 2019Cell Biology