Cell BiologybioRxiv
Patched regulates lipid homeostasis by controlling cellular cholesterol levels
C. E. Cadena Del Castillo, J. T. Hannich, A. Kaech…·A. Spang
This study identifies PTC-3 as a cholesterol transporter in C. elegans, showing that its loss causes cholesterol accumulation, ER defects, and lipid metabolism issues, which are rescued by reducing dietary cholesterol.
DOI 10.1038/s41467-021-24995-9